Groundbreaking simulations by Google Exacycle Visiting Faculty

Posted by David Konerding, Staff Software Engineer

In April 2011, we announced the Google Exacycle for Visiting Faculty, a new academic research awards program donating one billion core-hours of computational capacity to researchers. The Exacycle project enables massive parallelism for doing science in the cloud, and inspired multiple proposals aiming to take advantage of cloud scale. Today, we would like to share some exciting results from a project built on Google’s infrastructure.

Google Research Scientist Kai Kohlhoff, in collaboration with Stanford University and Google engineers, investigated how an important signalling protein in the membrane of human cells can switch off and on by changing its three-dimensional structure following a sequence of local conformational changes. This research can help to better understand the effects of certain chemical compounds on the human body and assist future development of more potent drug molecules with fewer side effects.

The protein, known as the beta-2 adrenergic receptor, is a G protein-coupled receptor (GPCR), a primary drug target that plays a role in several debilitating health conditions. These include asthma, type-2 diabetes, obesity, and hypertension. The receptor and its close GPCR relatives bind to many familiar molecules, such as epinephrine, beta-blockers, and caffeine. Understanding their structure, function, and the underlying dynamics during binding and activation increases our chances to decode the causes and mechanisms of diseases.

To gain insights into the receptor’s dynamics, Kai performed detailed molecular simulations using hundreds of millions of core hours on Google’s infrastructure, generating hundreds of terabytes of valuable molecular dynamics data. The Exacycle program enabled the realization of simulations with longer sampling and higher accuracy than previous experiments, exposing the complex processes taking place on the nanoscale during activation of this biological switch.

The paper summarizing the results of Kai’s and his collaborators’ work is featured on the January cover of Nature Chemistry, with artwork by Google R&D UX Creative Lead Thor Lewis, to be published on December 17, 2013. The online version of his paper was published on their website today.

We are extremely pleased with the results of this program. We look forward to seeing this research continue to develop.

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Google Faculty Research Awards Summer 2015

posted by Maggie Johnson, Director of Education and University Relations

We have just completed another round of the Google Faculty Research Awards, our annual open call for research proposals on Computer Science and related topics, including systems, machine learning, software engineering, security and mobile. Our grants cover tuition for a graduate student and provide both faculty and students the opportunity to work directly with Google researchers and engineers.

This round we received 805 proposals, about the same as last round, covering 48 countries on 6 continents. After expert reviews and committee discussions, we decided to fund 113 projects, with 27% of the funding awarded to universities outside the U.S. The subject areas that received the highest level of support were systems, machine perception, software engineering, and machine learning.

The Faculty Research Awards program plays a critical role in building and maintaining strong collaborations with top research faculty globally. These relationships allow us to keep a pulse on what’s happening in academia in strategic areas, and they help to extend our research capabilities and programs. Faculty also report, through our annual survey, that they and their students benefit from a direct connection to Google as a source of ideas and perspective.

Congratulations to the well-deserving recipients of this round’s awards. If you are interested in applying for the next round (deadline is October 15), please visit our website for more information.

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Google Faculty Research Awards Winter 2015

Posted by Maggie Johnson, Director of Education and University Relations

We have just completed another round of the Google Faculty Research Awards, our biannual open call for research proposals on Computer Science and related topics, including systems, machine perception, structured data, robotics, and mobile. Our grants cover tuition for a graduate student and provide both faculty and students the opportunity to work directly with Google researchers and engineers.

This round we received 808 proposals, an increase of 12% over last round, covering 55 countries on 6 continents. After expert reviews and committee discussions, we decided to fund 122 projects, with 20% of the funding awarded to universities outside the U.S. The subject areas that received the highest level of support were systems, human-computer interaction, and machine perception.

The Faculty Research Award program enables us to build strong relationships with faculty around the world who are pursuing innovative research, and plays an important role for Google’s Research organization by fostering an exchange of ideas that advances the state of the art. Each round, we receive proposals from faculty who may be just starting their careers, or who might be experimenting in new areas that help us look forward and innovate on whats emerging in the CS community.

Congratulations to the well-deserving recipients of this round’s awards. If you are interested in applying for the next round (deadline is April 15), please visit our website for more information.

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